Informatics Publishing Limited

Vishal V. Shah ¹, Smita J. Patil ¹, Nutan D. Shah ¹

Affiliations
1 Appasaheb Birnale College of Pharmacy, Sangli-416416, Maharashtra, IN

Abstract

A simple, accurate, sensitive, selective, precise and robust spectrophotometric method of analysis was suggested for determination of antiasthmatic drugs; Salmeterol xinafoate and Fluticasone propionate. The estimation of drugs was based on multicomponent mode of analysis, which involves the measurement of absorbance at two wavelengths 214 nm (λ_max of SX) and 246 nm (λ_max of FP). Phosphate buffer (pH 7.4): Ethanol (95%) (90:10) was used as solvent. The mean results of estimation for in capsule were 99.93±0.13 %&99.92±0.19 % for Salmeterol and Fluticasone respectively of the label claim. The proposed method was found to be linear in the range of 2 - 10 μg/ml with mean recovery in the range of 99.76% to 100.54%, for both the drugs. The developed new method was validated according to ICH guidelines and found to be accurate and precise. Thus the proposed method can be successfully applied for determination of Salmeterol xinafoate and Fluticasone propionate in routine analysis work.

Keywords

Salmeterol Xinafoate, Fluticasone Propionate, UV Spectroscopy, Multicomponent Mode, Capsule Dosage Form.

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Nutan V. Shah ¹, Shubhangi A. Patil ¹, Vishal V. Shah ², Madhavi N. Patil ³

Affiliations
1 KCT’S Krishna College of Pharmacy, Malkapur, Karad, IN
2 Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, IN
3 Krishna Institute of Medical Sciences Deemed University, Department of Genetics, Karad, IN

Abstract

Pharmacy practice has passed several rounds of advancements over the past few years. It had changed the traditional positioning criteria of pharmacists as business people into patient-centered healthcare professionals. This worldwide shift is increasingly accumulating pressure on pharmacists to turn up into better level of service providing accompanied with higher demand of inter-personal skills and intellectual capabilities. This can be accomplished through stressing the significance of continuing pharmacy education in basic sciences as well as social and administrative pharmacy techniques and its collaboration in elevating the quality of pharmacy practice.

Keywords

Pharmacy Practice, Continuing Pharmacy Education, Administrative Pharmacy.

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